The Holy Martyr Agrippina was a native of Rome who chose a life of celibacy, devoting herself entirely to God. During the persecution of Christians under Emperor Valerian (253–259), she courageously presented herself before the authorities and openly professed her faith in Christ.

For her bold confession, she was subjected to brutal torture. Beaten with rods so severely that her bones were broken, Saint Agrippina endured great suffering. She was then bound in chains, but an angel miraculously released her from her bonds.

Ultimately, she succumbed to the injuries inflicted upon her and died as a confessor of the faith. Devout Christian women—Bassa, Paula, and Agathonike—secretly retrieved her body and brought it to Sicily, where her tomb became a site of numerous miracles.

In the eleventh century, the relics of Saint Agrippina were transferred to Constantinople, where her memory continued to be honored.